Michael A. Taylor, Jiri Janousek, Vincent Daria, Joachim Knittel, Boris Hage, Hans-A. Bachor, Warwick P. Bowen
Quantum techniques allow the resolution constraints of classical imaging to be overcome, and are expected to have important applications in biology. We report the first demonstration of sub-diffraction limited quantum imaging in biology. Naturally occurring lipid granules of approximately 300nm diameter are used to image the local mechanical properties of the cellular cytoplasm, with spatial resolution enabled by thermal diffusion. Spatial structure is resolved at length scales down to 10nm. Our results confirm the longstanding prediction that use of quantum correlated light can enhance spatial resolution in biology, allowing a 14% enhancement over that achievable with coherent light. Combined with state-of-the-art sources of quantum correlated light, this technique provides a path towards an order of magnitude improvement in resolution over similar classical imaging techniques.
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http://arxiv.org/abs/1305.1353
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